Rajesh Chandramohanadas

Assistant Professor

Research Interests:

  • Mechanistic understanding of Egress and Invasion of Human Malaria parasites using multi-disciplinary approaches
  • Characterization of host-pathogen communication systems in parasitic infections
  • Identification of novel drug targets and targeted design of pharmacologically active scaffolds


Pillar / Cluster: Engineering Product Development, Science and Math

 

 

    Key Publications

    • Gowtham Subramanian, C. P. Babu Rajeev, CD Mohan, Ameya Sinha, Trang T. T. Chu, Sebastian Anusha, Huang Ximei, Julian E. Fuchs, Andreas Bender, KS. Rangappa, Rajesh Chandramohanadas* & Basappa* [Synthesis and in vitro evaluation of hydrazinyl phthalazines against malaria parasite, Plasmodium falciparum], Bioorganic and Medicinal Chemistry Letters
    • Megan K. Dearnley, Chu Thi Thu Trang, Yao Zhang, Oliver Looker, Changjin Huang, Nectarios Klonis, Jeff Yeoman, Shannon Kenny, Mohit Arora, James Osborne, Rajesh Chandramohanadas*, Sulin Zhang*, Matthew W.A. Dixon* and Leann Tilley* [Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages], Proceedings of the National Academy of Sciences (PNAS), USA.
    • Anusha Sebastian, Ameya Sinha, Babu Rajeev C.P, Trang TT Chu, Jessin Mathai, KS. Rangappa, Basappa and Rajesh Chandramohanadas* [Synthesis, characterization and in vitro evaluation of novel sulphonamide antimalarials], Organic and Biomolecular Chemistry.
    • Jee-Sun Cho, Bruce Russell, Varakorn Kosasaivee, Rou Zhang, Yves Colins, Olivier Bertrand, Rajesh Chandramohanadas, Cindy S. Chu, Francois Nosten, Laurent Renia, Benoit Malleret [Unambiguous determination of Plasmodium vivax reticulocyte invasion by flow cytometry, International Journal of Parasitology.
    • Ameya Sinha, Trang TT Chu, Ming Dao and Rajesh Chandramohanadas* [Single-cell evaluation of red blood cell bio-mechanical properties upon chemically induced mild oxidative stress], Scientific Reports, IF 5.2.
    • Gowtham Subramanian, Ameya Sinha, Chu Thi Thu Trang and Rajesh Chandramohanadas* [Chemical Biology and Proteomics for Hunting Drug Targets for Human Malaria: An Update] MOJ Proteomics and Bio-informatics Issue 5.
    • Rajesh Chandramohanadas, Basappa, Russell B, Liew K, Yau YH, Chong A, Liu M, Gunalan K, Raman R, Renia L, Nosten F, Shochat SG, Dao M, Sasisekharan R, Suresh S and Peter Preiser. [Small Molecule Targeting Malaria Merozoite Surface Protein-1 (MSP-1) Prevent Host Invasion by Divergent Plasmodia], Journal of Infectious Diseases.
    • Millholland MG*, Rajesh Chandramohanadas*, Pizzarro A, Wehr A, Shi H, Darling C, Lim CT, Greenbaum DC [The Malaria Parasite Progressively Dismantles the Host Erythrocyte Cytoskeleton for Efficient Egress], #Shared First Author, Molecular & Cellular Proteomics.
    • Rajesh Chandramohanadas, Park Y, Lui L, Li A, Quinn D, Liew K, Diez-Silva M, Sung Y, Dao M, Lim CT, Preiser PR and Suresh S. [Bio-physics of Malarial Parasite Exit From Infected Erythrocytes] PLoS ONE.
    • Lucumi E, Darling C, Jo H, Napper AD, Rajesh Chandramohanadas, Fisher N, Shone AE, Jing H, Ward SA, Biagini GA, DeGrado WF, Diamond SL and Greenbaum DC [Discovery of potent small molecule inhibitors of multi‐drug resistant P. falciparum using a novel miniaturized highthroughput luciferase-based assay], Antimicrobial Agents & Chemotherapy.
    • Rajesh Chandramohanadas, Davis PH, Beiting DP, Harbut MB, Darling C, Velmourougane G, Lee MY, Greer PA, Roos DS and Greenbaum DC [Apicomplexan Parasites Co‐opt Host Calpains to Facilitate Their Escape from Infected Host Cells], Science.
    • Harbut MB, Velmourougane G, Reiss G, Rajesh Chandramohanadas and Greenbaum DC. [Development of bestatin-based activity-based probes for metallo-aminopeptidases], Bioorganic and Medicinal Chemistry Letters.
      Workflow: 
      Published